The demand for fast, reliable DNA and RNA oligonucleotide synthesis continues to rise across molecular biology, diagnostics, biotechnology, and synthetic biology. Choosing the right oligonucleotide synthesizer in 2026 is critical for productivity, budget efficiency, and long-term scalability.

This guide provides a comprehensive overview of the key factors to consider, and how Biolytic’s Dr. Oligo Series (Dr. Oligo 12, Dr. Oligo 48, Dr. Oligo 192XLc, and Dr. Oligo 768XLc) compares across research and production needs.

What to Consider When Choosing an Oligonucleotide Synthesizer

These factors determine which DNA/RNA synthesizer is right for your lab:

1. Oligo Throughput Requirements

The first and most important question:
How many oligos do you need per day, week, or month?

By understanding your expected throughput, you can identify whether a low-throughput, mid-throughput, high-throughput, or ultra-high throughput, industrial-scale oligo synthesizer is the best fit for your workflow.

2. Sequence Complexity & Chemistry Flexibility

For scientists running advanced workflows, consider whether you require:

Long DNA or RNA sequences
Modified nucleotides
Specialty backbone chemistries
Custom column compatibility

Flexible chemistry support reduces workflow limitations. Our range of Dr. Oligo synthesizers covers all needs with expansive reagent capability and customization to synthesize any oligo needed.

3. Total Cost of Ownership (TCO)

Purchasing managers often evaluate:

Instrument price
Cost per oligo
Reagent and consumable usage
Maintenance requirements
System uptime and longevity

A reliable synthesizer reduces outsourcing costs and delays, while providing security and privacy for proprietary experiments and research.

4. Scalability & Future Growth

Choose a system that supports current needs and projected growth.
A scalable platform minimizes the need for future reinvestment and ensures long-term workflow continuity. The Dr. Oligo is fully customizable allowing for upgrades past time of purchase when your needs change. The Dr. Oligo synthesizers use easy to find parts and consumables, allowing you to grow the way you want, and not locking you into a closed proprietary system.

Dr. Oligo Series: Which Model Fits Your Needs?

Biolytic’s Dr. Oligo lineup covers every stage and need, from R&D to full-scale production.

🔬 Dr. Oligo 12 — Oligonucleotide Synthesizer for Low-Throughput Labs

Best for:

Small R&D labs
Academic groups
Labs starting in-house synthesis
Any institution who has low oligo throughput needs

Key Advantages:

Synthesizes 12 oligos per run
Use up to 42 reagents for simple or complex oligos
Compact, cost-effective DNA/RNA synthesizer
Supports DNA, RNA, and modified chemistries
Great for on-demand primers, probes

Why choose it:
Affordable entry into in-house oligo synthesis with fast turnaround. Low throughput of DNA RNA oligos with the use up to 42 reagents, allowing flexibility for any type of oligo.

🔬 Dr. Oligo 48 — Mid-Throughput DNA/RNA Synthesizer for Synthesis Flexibility

Best for:

Institutions with medium throughput oligo needs
Researchers with flexible oligo sequence needs, simple or complex

Key Advantages:

48 oligos per run
Up to 42 reagents for simple or complex oligos
Balanced throughput and workflow flexibility
Fully customizable configuration
Use standard or custom columns

Why choose it:
Balanced throughput capability with expansive reagent capability, allowing for simple or complex oligos for r&d or production use.

🔬 Dr. Oligo 192XLC — High-Throughput Oligonucleotide Production System

Best for:

Institutions with High-throughput production needs

Key Advantages:

Up to 192 oligos per run
Use up to 49 reagents
Supports column formats as well as 96-well plate formats for flexibility between r&d and production
Built for consistency and daily production cycles

Why choose it:
A powerful step into professional, reliable high-throughput oligo manufacturing with the flexibility to use up to 49 reagents.

🔬 Dr. Oligo 768XLC — Ultra-High-Throughput DNA/RNA Oligo Synthesizer

Best for:

Research facilities needing ultra-high oligo throughput

Key Advantages:

768 oligos per run
Up to 25 max reagents
Engineered for 24/7 operation
Maximum efficiency for large-scale workflows

Why choose it:
The premier choice for ultra-high throughput and commercial oligo production.

Quick Comparison Guide

Research or Business Need	Best Dr. Oligo Model
Occasional or low-volume synthesis	Dr. Oligo 12
Growing lab with routine synthesis needs	Dr. Oligo 48
High-throughput production	Dr. Oligo 192XLC
Industrial-scale, ultra-high-throughput output	Dr. Oligo 768XLC

Why Choose the Dr. Oligo Series?

Whether you’re optimizing research workflows or evaluating long-term investment value, Biolytic’s DNA/RNA synthesizers deliver:

✔ Proven Reliability

Trusted worldwide in both research and production environments for over 30 years.

✔ Low Cost of Ownership

Efficient reagent use, low consumable costs, and long machine lifespan with options for upgrades and customization.

✔ Workflow Flexibility

Supports DNA, RNA, modified oligos, and custom columns.

✔ Strong Technical Support & Training

Responsive guidance ensures maximum uptime and successful onboarding and ongoing synthesis.

✔ Scalable Options

From 12 to 768 oligos per run, and expansive reagent capability, choose what fits now and upgrade as you grow.

Conclusion: The Right Oligonucleotide Synthesizer Sets You Up for Success in 2026

Selecting the best DNA/RNA oligonucleotide synthesizer is a major step toward improving speed, efficiency, and independence in oligo production. Biolytic’s Dr. Oligo Series offers reliable, scalable solutions for any lab, from small R&D teams to industrial production facilities.

If you need help getting started with oligo synthesis, or choosing between Dr. Oligo models, Biolytic’s team can provide a tailored recommendation.

Ready to find the right oligo synthesizer? Contact Biolytic Lab Performance today for our Biolytic Product Catalog, or to Schedule a personalized presentation call.